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For the most recent publications, please visit Pubmed.

Project 1: Lipin proteins—masters of fat synthesis

Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle. Zhang P, Verity MA, Reue K. Cell Metab. 2014 Aug 5;20(2):267-79. doi: 10.1016/j.cmet.2014.05.003. Epub 2014 Jun 12. Lipin-1 and lipin-3 together determine adiposity in vivo. Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K. Mol Metab. 2013 Nov 28;3(2):145-54. doi: 10.1016/j.molmet.2013.11.008. eCollection 2014 Apr. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2486-95. doi: 10.1073/pnas.1205221109. Epub 2012 Aug 20. Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis. Zhang P, Takeuchi K, Csaki LS, Reue K. J Biol Chem. 2012 Jan 27;287(5):3485-94. doi: 10.1074/jbc.M111.296681. Epub 2011 Dec 6. Lipin, a lipodystrophy and obesity gene. Phan J, Reue K. Cell Metab. 2005 Jan;1(1):73-83.

Project 2: Diet1 and resistance to high cholesterol levels and cardiovascular disease

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K. Cell Metab. 2013 Jun 4;17(6):916-28. doi: 10.1016/j.cmet.2013.04.007. Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis. Reue K, Lee JM, Vergnes L. Dig Dis. 2015;33(3):307-13. doi: 10.1159/000371649. Epub 2015 May 27.

Project 3: Pharmacogenomics of statin drugs

Publications coming soon!

Project 4: Sex differences in obesity

Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression. Link JC, Hasin-Brumshtein Y, Cantor RM, Chen X, Arnold AP, Lusis AJ, Reue K. BMC Genomics. 2017 Jan 17;18(1):89. doi: 10.1186/s12864-017-3484-1. Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes. Link JC, Chen X, Prien C, Borja MS, Hammerson B, Oda MN, Arnold AP, Reue K. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1778-86. doi: 10.1161/ATVBAHA.115.305460. Epub 2015 Jun 25. Metabolic impact of sex chromosomes. Link JC, Chen X, Arnold AP, Reue K. Adipocyte. 2013 Apr 1;2(2):74-9. doi: 10.4161/adip.23320. The number of X chromosomes causes sex differences in adiposity in mice. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. PLoS Genet. 2012;8(5):e1002709. doi: 10.1371/journal.pgen.1002709. Epub 2012 May 10.

Project 5: Brown adipose tissue and energy metabolism

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma. Vergnes L, Davies GR, Lin JY, Yeh MW, Livhits MJ, Harari A, Symonds ME, Sacks HS, Reue K. J Clin Endocrinol Metab. 2016 Aug 30:jc20162670. [Epub ahead of print] Zbtb16 has a role in brown adipocyte bioenergetics. Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L. Nutr Diabetes. 2012 Sep 17;2:e46. doi: 10.1038/nutd.2012.21. Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. Vergnes L, Chin R, Young SG, Reue K. J Biol Chem. 2011 Jan 7;286(1):380-90. doi: 10.1074/jbc.M110.184754. Epub 2010 Nov 1.

Laboratory of Karen Reue | Human Genetics | David Geffen School of Medicine | UCLA