The American Journal of Human Genetics, April 2003 (vol. 72):

Combined Analysis of Genome Scans of Dutch and Finnish Families Reveals a Susceptibility Locus for High-Density Lipoprotein Cholesterol on Chromosome 16q

Päivi Pajukanta1, Hooman Allayee1, Kelly L. Krass2,3, Ali Kuraishy1, Aino Soro1,7, Heidi E. Lilja1,8, Rebecca Mar1, Marja-Riitta Taskinen7, Ilpo Nuotio9, Markku Laakso10, Jerome I. Rotter1,3,4,6, Tjerk W.A. de Bruin11, Rita M. Cantor1,4, Aldons J. Lusis1,2,3,5 and Leena Peltonen1,8

Departments of 1Human Genetics, 2Microbiology and Molecular Genetics, 3Medicine, and 4Pediatrics, and 5Molecular Biology Institute, David Geffen School of Medicine at UCLA. 6Division of Medical Genetics, Steven Spielberg Pediatric Research Center and Cedars-Sinai Research Institute, Los Angeles, CA. 7Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. 8Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, and Department of Medical Genetics, University of Helsinki, Finland. 9Department of Medicine, Turku University Central Hospital, Turku, Finland. 10Department of Medicine, Kuopio University Central Hospital, Kuopio, Finland. 11Department of Medicine and the Cardiovascular Research Institute Maastricht (CARIM), Academic Hospital, Maastricht, The Netherlands

Address correspondence to: Päivi Pajukanta, MD, PhD, Assistant Professor, Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, Room 6309A, 695 Charles E. Young Drive South, Los Angeles, California 90095-7088, USA.

E-mail: ppajukanta@mednet.ucla.edu and Leena Peltonen, Biomedicum Helsinki, Haartmanink. 8, 00250 Helsinki, Finland. Email: Leena.Peltonen@ktl.fi

Published in The American Journal of Human Genetics, in the April 2003 issue, Volume 72, and in the web site of The American Journal of Human Genetics in March, 2003 (http://www.journals.uchicago.edu/AJHG/)


The following data files can be downloaded for the complete results of the pooled data analyses:

1. The two-point results of all genome scan markers in pooled data analysis of the Finnish and Dutch FCHL families, using the 90th percentile familial combined hyperlipidemia (FCHL) trait.
2.1. The two-point results of all genome scan markers in pooled data analysis of the Finnish and Dutch FCHL families, using the 90th percentile total cholesterol (TC) trait.
3.1. The two-point results of all genome scan markers in pooled data analysis of the Finnish and Dutch FCHL families, using the 90th percentile apolipoprotein B (apoB) trait.
4.1. The two-point results of all genome scan markers in pooled data analysis of the Finnish and Dutch FCHL families, using the 90th percentile triglyceride (TG) trait.
5.1. The two-point results of all genome scan markers in pooled data analysis of the Finnish and Dutch FCHL families, using the 10th percentile high-density lipoprotein cholesterol (HDL-C) trait.