Selected Publications

Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis AJ. (2016) Genetic dissection of cardiac remodeling in an isoproterenol-induced heart failure mouse model. PLoS Genet. 12: e1006038.
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL. (2015) Non-lethal Inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163: 1585-95.
Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. (2015) Genetic architecture of insulin resistance in the mouse. Cell Metab. 21: 334-46.
Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ. (2015) Genetic and environmental control of host-gut microbiota interactions. Genome Res. 25: 1558-69.
Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ (2015) Genetic architecture of atherosclerosis in mice: A systems genetics analysis of common inbred strains. PLoS Genetics 11: e1005711. Erratum in: PLoS Genet. 2016 Mar;12:e1005913
Civelek M, Lusis AJ. (2014) Systems genetics approaches to understand complex traits. Nat. Rev. Genet. 15: 34-48.
Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. (2013) Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 17: 141-52.
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, Didonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 19: 576-85.
Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne P, Saleem NK, Cederberg H, Kuusisto J, Gargalovic P, Kirchgessner T, Laakso M, Lusis AJ. (2013) Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum Mol Genet. 22: 3023-37.
Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen S, Lusis AJ. (2013) Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 17: 49-60.
Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan A, Che N, Wen P, Qi, HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis AJ. (2012) Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 151: 658-70.
Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakobowski H, Lusis AJ. (2012) The effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation 126: 1896-906.
Arnold AP, Lusis AJ (2012) Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology 153: 2251-5.
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472: 57-63.
Ghazalpour A, Bennett B, Petyuk VA, Orozco L, Hagopian R, Mungrue IN, Farber CR, Sinsheimer J, Kang HM, Furlotte N, Park CC, Wen PZ, Brewer H, Weitz K, Camp DG 2nd, Pan C, Yordanova R, Neuhaus I, Tilford C, Siemers N, Gargalovic P, Eskin E, Kirchgessner T, Smith DJ, Smith RD, Lusis AJ. (2011) Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet. 7: e1001393.
Farber CR, Bennett BJ, Orozco L, Zou W, Lira A, Kostem E, Kang HM, Furlotte N, Berberyan A, Ghazalpour A, Suwanwela J, Drake TA, Eskin E, Wang QT, Teitelbaum SL, Lusis AJ. (2011) Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet. 7: e1002038.
Romanoski CE, Lee S, Kim MJ, Ingram-Drake L, Plaisier CL, Yordanova R, Tilford C, Guan B, He A, Gargalovic PS, Kirchgessner TG, Berliner JA, Lusis AJ. (2010) Systems genetics analysis of gene-by-environment interactions in human cells. Am J Hum Genet. 86: 399-410.
Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang W, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani L, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ (2010) A high resolution association mapping panel for the dissection of complex traits in mice. Genome Res. 20: 281-90.
Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, (2009) Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 41: 415-23.
Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L, Wang S, van Nas A, Che N, Araujo JA, Pellegrini M, Lusis AJ. (2009) Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet. 18: 4118-29.
Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, Brozell A, Castellanos R, Eskin E, Smith DJ, Drake TA, Lusis AJ. (2008) High-resolution mapping of gene expression using association in an outbred mouse stock. Proc. Nat. Acad. Sci. USA 407: e1000149.
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, Macneil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE. (2008) Variations in DNA elucidate molecular networks that cause disease. Nature 452: 429-35.
Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ. (2007) Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ. Res. 101: e11-30.
Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ. (2007) Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci USA 104: 4530-5.
Gargalovic PS, Imura M, Zhang B, Gharavi NM, Clark MJ, Pagnon J, Yang W-P, Truong A, Patel S, Nelson SF, Horvath S, Berliner JA, Kirchgessner TG, Lusis AJ. (2006) Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc. Nat. Acad. Sci. USA 103: 12741-6.
Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ. (2006) Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2: e15.
Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, Lusis AJ. (2006) The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol. 26: 2490-6.
Doss S, Schadt EE, Drake TA, Lusis AJ. (2005) Cis-acting expression quantitative trait loci in mice. Genome Res. 15: 681-91.
Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. (2005) An integrative genomics approach to infer causal associations between gene expression and disease. Nat. Genet. 37: 710-717. (Top ten list for breakthrough of the year, 2005, as determined by Science editorial staff, featured in Dec. 23, 2005, issue of Science).
Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss RM, Sinsheimer JS, Cantor RM, De Bruin TW, Lusis AJ. (2004) Association of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ. Res. 94: 993-999.
Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM. (2002) Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation 106: 484-490.
Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ. (2002) Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat. Genet. 30: 110-116.
Brennan ML, Anderson MM, Shih DM, Qu XD, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, Lusis AJ. (2001) Increased atherosclerosis in myeloperoxidase-deficient mice (with commentary by W.N. Nauseef on pp. 401-403). J. Clin. Invest. 107: 419-430.
Lusis AJ (2000) Atherosclerosis. Nature 407: 233-241.
Shi W, Haberland ME, Shih DM, Jien ML, Lusis AJ. (2000) Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice (with commentary by J. Breslow on pp. 5-6). Circulation 102: 75-81.
Aouizerat BE, Allayee H, Cantor RM, Davis RC, Lanning CD, Wen PZ, DallingaThie GM, deBruin TWA, Rotter JI, Lusis AJ. (1999) A genome scan for familial combined hyperlipidemia reveals evidence for a locus on chromosome 11. Am. J. Hum. Genet. 65: 397-412.
Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. (1998) Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394: 284-287.
Rajavashisth T, Qiao JH, Mishra N, Tripathi S, Tripathi J, Wang X, Loussararian A, Clinton S, Libby P, Lusis AJ. (1998) Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor deficient mice. J. Clin. Invest. 101: 2702-2710.
Mehrabian M, Wen PZ, Fisler J, Davis RC, Lusis AJ. (1998) Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J. Clin. Invest. 101: 2485-2496.