About Us

The Kruglyak Lab conducts experiments in model organisms, as well as computational analyses, aimed at understanding how changes at the level of DNA are shaped by molecular and evolutionary forces, and how these changes lead to all the observable differences among individuals within a species.

Dr. Kruglyak has also been an Investigator with the Howard Hughes Medical Institute (HHMI) since 2008, working towards understanding the genetic basis of phenotypic variation in species.

Latest News

  • June 2016: We are pleased to announce that Dr. Leonid Kruglyak has been appointed Chair of the Department of Human Genetics, effective July 1, 2016. The news announcement can be read here.

  • May 2016: New genetic mapping approach intrigues media
    The Scientist published a May 5 article showcasing a new technique developed by researchers Meru Sadhu and Joshua Bloom, in the laboratory of Leonid Kruglyak, to manipulate chromosome recombination, allowing high-resolution genetic mapping of phenotypic traits in yeast. His laboratory’s findings were published in Science.

  • May 2016: We are pleased to announce that Daniel Leighton, PhD, will be joining our lab in August as a Postdoctoral Scholar. Daniel received his doctoral degree from California Institute of Technology in Spring 2016. His research in the Paul Sternberg Laboratory focused on the behavioral, metabolic and transcriptional changes associated with aging and sperm depletion in Caenorhabditis elegans. In 2014, he published his discovery of a new mating pheromone in this species, as well as its regulation by reproductive events. His doctoral thesis focused on the search for genes that are responsible for this regulation.

  • March 2016:Congratulations to Olga Schubert, PhD, recipient of a three-year postdoctoral fellowship from the Human Frontiers Science Foundation (HFSP) for her project proposal "Surveying the complete space of genetic loci influencing protein abundance." HFSP is an international program funding frontier research on the complex mechanisms of living organisms. HSCP fellowships support top postdoctoral researchers who propose innovative, ground-breaking projects that have the potential to advance the knowledge in their field of study and open a new approach to the research problem.